howtosupplement
Performance/Hormonal/Cognition

Sulbutiamine

Synthetic thiamine derivative studied for chronic fatigue and erectile dysfunction, with limited but promising older clinical data in specific populations.

Sulbutiamine

Sulbutiamine

40
score
C
evidence
Caution
risk
Quick Take

Niche option for chronic fatigue or psychogenic ED; evidence is small and dated, so most users should prioritize better-studied alternatives

Sulbutiamine is a fat-soluble synthetic derivative of thiamine (vitamin B1) that crosses the blood-brain barrier more efficiently than standard thiamine. Used in some countries for functional asthenia, it increases central thiamine pyrophosphate and modulates glutamatergic and dopaminergic signaling. Small human studies suggest reduced fatigue, with very limited evidence for improved erectile function and memory. Best suited for those with persistent unexplained fatigue or psychogenic erectile dysfunction, though the evidence base is narrow and decades old.

Proven Benefits

01
Reduces fatigue/asthenia
02
May improve erectile function
03
May support memory/attention

Protocol

Amount
200-600 mg
Frequency
Once daily, or split into two doses
When
Morning and early afternoon; avoid late-day dosing to prevent sleep disturbance.

Onset Time

1-3 weeks for fatigue benefits; acute alertness effects are possible but less st

Who Should Consider

Adults with chronic functional asthenia
Men with psychogenic erectile dysfunction
Patients with post-viral fatigue
Those seeking non-stimulant fatigue options

How It Works

Sulbutiamine crosses the blood-brain barrier and increases thiamine pyrophosphate in neural tissue, supporting central energy metabolism. Preclinical studies suggest modulation of glutamate and dopamine signaling, while small human trials indicate reduced somatic and psychic fatigue, possibly via enhanced cholinergic tone. Exact molecular targets in humans remain incompletely characterized.

Updated Invalid Date