howtosupplement
Mood/Cognition/Immunity

Selank

Synthetic peptide studied for anxiety and cognitive support, with evidence limited to small Russian clinical trials.

Selank

Selank

38
score
C
evidence
Caution
risk
Quick Take

Skip unless you are participating in supervised research; evidence is too preliminary for general use.

Selank is a synthetic heptapeptide and tuftsin analog developed in Russia. It is primarily investigated as an anxiolytic and nootropic compound. Russian clinical studies suggest it may reduce anxiety without causing sedation or withdrawal. Limited small trials also examine cognitive performance under stress and immunomodulatory effects. It is not approved by the FDA or EMA and remains experimental outside Russia. Those considering it typically have treatment-resistant anxiety and are working with a clinician.

Proven Benefits

01
Reduces anxiety
02
May improve cognitive function
03
May enhance stress resilience
04
May support immune response

Protocol

Amount
250-500 mcg
Frequency
Once or twice daily
When
Intranasal or subcutaneous administration per clinical protocol; not for oral use.

Onset Time

Days to 2 weeks for mood effects; cognitive changes unclear

Who Should Consider

Adults with treatment-resistant anxiety
Those in supervised peptide research
People seeking non-sedating anxiolytics

How It Works

Selank is thought to modulate brain-derived neurotrophic factor (BDNF) expression and inhibit enkephalin-degrading enzymes, potentially enhancing GABAergic signaling. It may also influence interferon and cytokine production, though human mechanisms are not fully characterized.

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