howtosupplement
Cognition/Sleep/Mood

Pregnenolone

Neurosteroid precursor studied for cognitive and sleep effects, primarily in small clinical trials for schizophrenia and mood disorders.

Pregnenolone

Pregnenolone

36
score
C
evidence
Caution
risk
Quick Take

Skip for general use — evidence is limited to small trials in specific psychiatric populations, and long-term hormonal safety is unknown.

Pregnenolone is an endogenous steroid synthesized from cholesterol, serving as the biochemical precursor to progesterone, cortisol, DHEA, and sex hormones. In the brain, it and its sulfate ester act as neurosteroids that modulate GABA-A, NMDA, and other receptors. Small randomized trials suggest it may improve attention and working memory in schizophrenia and alter sleep architecture, though data in healthy adults are scarce. It is sometimes explored for cognitive concerns or sleep quality, but routine use is not supported by robust evidence. Those most likely to be studied candidates are indi

Proven Benefits

01
May improve cognitive function
02
May increase deep sleep
03
May support mood stability

Protocol

Amount
25-100 mg
Frequency
Once daily
When
Morning, with food to minimize GI upset.

Onset Time

2-6 weeks in clinical trials

Who Should Consider

Adults with schizophrenia under psychiatric supervision
Individuals with documented neurosteroid abnormalities
People enrolled in neurosteroid clinical trials

How It Works

Pregnenolone is converted in the body into downstream steroid hormones including progesterone, DHEA, and cortisol. In the central nervous system, it acts as a neurosteroid that positively modulates NMDA receptor signaling and negatively modulates GABA-A receptors, potentially enhancing synaptic plasticity and neuronal excitability. These mechanisms are hypothesized to underlie observed effects on

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