howtosupplement
Cognition/Performance/Mood

Phenylpiracetam

Synthetic racetam compound studied for cognitive and fatigue effects in cerebrovascular insufficiency, with limited human evidence.

Phenylpiracetam

Phenylpiracetam

42
score
C
evidence
Caution
risk
Quick Take

Weak evidence from small Russian trials; skip in favor of better-studied cognitive supplements.

Phenylpiracetam is a synthetic racetam derivative developed in Russia as a prescription drug (Phenotropil); it is not approved as a dietary supplement in the US. The added phenyl group increases lipophilicity and confers psychostimulant properties, likely via modulation of acetylcholine, glutamate, and dopamine signaling. Small Russian clinical trials suggest modest improvements in cognitive function, fatigue, and functional recovery after stroke in specific patient groups. Healthy adults have almost no published data, making recreational use experimental. It may be considered by individuals w

Proven Benefits

01
May improve cognitive function
02
May reduce fatigue
03
May support post-stroke recovery
04
May reduce depressive symptoms

Protocol

Amount
100-200 mg
Frequency
Once daily, morning
When
Morning, with food to reduce GI upset; avoid afternoon or evening due to stimulant effects.

Onset Time

Acute within 1-2 hours; cumulative effects noted over 2-4 weeks.

Who Should Consider

Adults with cerebrovascular insufficiency
People with persistent asthenia
Patients in post-stroke rehabilitation
Healthy adults experimenting with nootropics

How It Works

The phenyl group increases lipophilicity and confers psychostimulant properties, likely via dopamine reuptake inhibition and modulation of nicotinic acetylcholine and NMDA receptors. This is thought to increase neuronal excitability and neurotransmitter release, though direct human mechanistic data remain sparse.

Updated Invalid Date