Heart/Inflammation/Mood

Omega-3

EPA/DHA fats from fish or algae that lower triglycerides and may support heart and inflammatory health in adults with low fish intake.

Omega-3

Omega-3

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Quick Take

Strong evidence for triglycerides and modest heart benefits — most worth it if you rarely eat fatty fish.

Omega-3 usually refers to the long-chain fats EPA and DHA from oily fish, fish oil, and algal oil. They integrate into cell membranes, lower liver triglyceride output, and shift signaling toward less inflammatory eicosanoids and more pro-resolving mediators. Best-backed benefits are lower triglycerides, small blood-pressure improvements, and possible cardiovascular benefit, with smaller evidence for mood and joint symptoms. Adults who rarely eat fatty fish tend to benefit most.

Proven Benefits

01
Lowers triglycerides
02
Modestly lowers blood pressure
03
Modestly lowers CV event risk
04
Reduces depressive symptoms
05
Lowers CRP and IL-6
06
May ease joint pain/stiffness
07
May improve dry eye symptoms

Protocol

Amount
1000-2000 mg EPA+DHA
Frequency
Once daily or split into 2 doses with meals
When
With a meal containing fat; this matters most for ethyl ester forms.

Onset Time

4-8 weeks for subjective effects, 8-12 weeks for lipids and omega-3 index.

Who Should Consider

Adults who eat fatty fish less than 2x/week
People with elevated triglycerides
Vegetarians and vegans using algal oil
Adults 50+ with low seafood intake
People with a low omega-3 index

Food Sources

  • Salmon (~1.5-2.2 g EPA+DHA per 100 g)
  • Sardines (~1.0-1.5 g EPA+DHA per 100 g)
  • Mackerel (~1.5-2.5 g EPA+DHA per 100 g)
  • Herring (~1.5-2.0 g EPA+DHA per 100 g)
  • Trout (~0.8-1.0 g EPA+DHA per 100 g)
  • Omega-3 eggs (~100-150 mg per egg)

How It Works

EPA and DHA are built into cell membranes, where they partly replace arachidonic acid and change the balance of eicosanoids and resolvins toward less inflammatory signaling. They also reduce liver VLDL production, which is why triglycerides fall.

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