howtosupplement
Cognition/Mood/Sleep

Noopept

Synthetic nootropic peptide studied for mild cognitive impairment, with limited evidence in healthy adults.

Noopept

Noopept

36
score
C
evidence
Caution
risk
Quick Take

Only clearly studied in cognitively impaired populations; no reliable evidence for healthy adults.

Noopept is a synthetic dipeptide nootropic developed in Russia and closely related to piracetam. It is prescribed in some countries for mild cognitive impairment and traumatic brain injury. It is thought to modulate glutamate and acetylcholine neurotransmission and may increase brain-derived neurotrophic factor (BDNF). Small Russian clinical trials suggest it may improve memory and attention in older adults with cognitive decline, though replication in Western research is lacking. Evidence in healthy adults is essentially nonexistent. It may be considered by those with diagnosed cognitive impa

Proven Benefits

01
May improve cognition in MCI
02
May aid brain injury recovery
03
May reduce anxiety
04
May improve sleep quality

Protocol

Amount
10-30 mg
Frequency
Once or twice daily
When
Morning or early afternoon with food; avoid late-day dosing due to potential insomnia.

Onset Time

Acute within 1-2 hours; cognitive benefits in 4-8 weeks for clinical populations

Who Should Consider

Adults with mild cognitive impairment
Individuals recovering from brain injury
Older adults with cerebrovascular insufficiency
Healthy adults interested in experimental nootropics

How It Works

Noopept is believed to modulate glutamatergic signaling via AMPA and NMDA receptors and enhance cholinergic transmission in the hippocampus. Animal studies indicate it increases expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which could support synaptic plasticity. These mechanisms are established primarily in preclinical models; human mechanistic data are li

Updated Invalid Date